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In their recently published Outcome Reduction with Initial Glargine Intervention (ORIGIN) trial (1), the investigators found that basal insulin glargine started early in the natural history of dysglycemia can maintain glycemic control near baseline levels for the whole study length. This trial is important for the size (12,537 individuals), geography (40 countries), and follow-up (up to 5 years). During glargine treatment, the percentage of diabetic patients achieving A1C <7.0% (53 mmol/mol) was 88% at 1 year and 77% at 5 years, and the percentage achieving A1C <6.5% (48 mmol/mol) was 74% at 1 year and 60% after 5 years. These percentages of success …

diabetes care

Comment on: The ORIGIN Trial Investigators. Characteristics Associated With Maintenance of Mean A1C <6.5% in People With Dysglycemia in the ORIGIN Trial. Diabetes Care 2013;36:2915-2922