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Kan et al. (1) conducted a meta-analysis on the relationship between depression and insulin resistance (IR), targeting 25 datasets from 18 studies. They calculated the pooled odds ratio using random-effects models and observed a small but significant association between depression and IR.Before their results can be accepted, I would like to express two concerns in relation to their meta-analysis. First, Kan et al. included articles adopting different definitions for depression. In this connection, they mentioned that the magnitude …

diabetes care

Comment on: Kan et al. A Systematic Review and Meta-analysis of the Association Between Depression and Insulin Resistance. Diabetes Care 2013;36:480–489