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Satoh-Asahara et al. (1) recently reported that treatment with purified eicosapentaenoic acid (EPA; 1.8 g daily) for 3 months increases the serum EPA/arachidonic acid (AA) ratio and interleukin-10 levels of peripheral blood monocytes in association with slight decreases in the pulse wave velocity, an index of arterial stiffness, in obese patients with dyslipidemia. Pulse wave velocity values before treatment with or without EPA were almost within the age-associated normal range (around the age-associated healthy average + 1 SD) in these Japanese subjects. The clinical value of treatment with purified EPA for the primary prevention of atherosclerosis and/or cardiovascular disease, however, remains uncertain. …

diabetes care

Comment on: Satoh-Asahara et al. Highly Purified Eicosapentaenoic Acid Increases Interleukin-10 Levels of Peripheral Blood Monocytes in Obese Patients With Dyslipidemia. Diabetes Care 2012;35:2631–2639