Comment on: Aeberli et al. Moderate Amounts of Fructose Consumption Impair Insulin Sensitivity in Healthy Young Men: A Randomized Controlled Trial. Diabetes Care 2013;36:150–156

A recent article by Aeberli et al. (1) concluded that moderate amounts of fructose and sucrose “clearly” and significantly alter hepatic insulin sensitivity and lipid metabolism compared with glucose. The authors’ data do not support their conclusions, however, due to experimental design limitations, data variability, and undemonstrated clinical significance at moderate fructose doses.First, the authors properly reported baseline daily intake data for energy, sugars, and fibers in Table 3 of ref. 1 but neglected to do so for the crux of the article—the metabolic markers and measures of glucose metabolism reported in Tables 1 and 2 of ref. 1. Although the authors noted this limitation, as well as the short duration of the intervention (3 weeks), …