Comment on: Rizzo et al. Reduction of Oxidative Stress and Inflammation by Blunting Daily Acute Glucose Fluctuations in Patients With Type 2 Diabetes: Role of Dipeptidyl Peptidase-IV Inhibition. Diabetes Care 2012;35:2076–2082 | Zendy

Antoine Makdissi | Zendy; Ajay Chaudhuri | Zendy; Nitesh Kuhadiya | Zendy; Manav Batra | Zendy; Paresh Dandona | Zendy

Open Access

Comment on: Rizzo et al. Reduction of Oxidative Stress and Inflammation by Blunting Daily Acute Glucose Fluctuations in Patients With Type 2 Diabetes: Role of Dipeptidyl Peptidase-IV Inhibition. Diabetes Care 2012;35:2076–2082

Author(s) -

Antoine Makdissi,

Ajay Chaudhuri,

Nitesh Kuhadiya,

Manav Batra,

Paresh Dandona

Publication year - 2013

Publication title -

diabetes care

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 6.636

H-Index - 363

eISSN - 1935-5548

pISSN - 0149-5992

DOI - 10.2337/dc12-2220

Subject(s) - sitagliptin , medicine , vildagliptin , diabetes mellitus , oxidative stress , type 2 diabetes , glycemic , dipeptidyl peptidase 4 , endocrinology , concomitant , inflammation

In their interesting study on the concomitant reduction in inflammatory and oxidative stress and mean amplitude of glycemic excursions (MAGE) following treatment with dipeptidyl peptidase-IV (DPP-4) inhibitors, sitagliptin and vildagliptin, in patients with type 2 diabetes, Rizzo et al. (1) propose that the reduction in MAGE leads to the reduction in indices of oxidative and inflammatory stress. However, the recent demonstration that sitagliptin exerts a rapid and potent …

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