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The article in Diabetes Care by Singer et al. (1) elegantly showed that higher adiponectin was independently associated with increased all-cause mortality in elderly subjects with type 2 diabetes mellitus (T2DM). This was in contrary to the authors’ hypothesis that higher adiponectin level would be associated with lower all-cause mortality given the anti-inflammation, antiatherogenic, and insulin-sensitizing properties of adiponectin. The authors alluded to the important association between elevated adiponectin and chronic kidney disease, which could have contributed to increased mortality. However, they conceded that …

Comment on: Singer et al. Adiponectin and All-Cause Mortality in Elderly People With Type 2 Diabetes. Diabetes Care 2012;35:1858–1863