Response to Comment on: Harrison et al. β-Cell Function Preservation After 3.5 Years of Intensive Diabetes Therapy. Diabetes Care 2012;35:1406–1412

We appreciate the critical review of our article by Aizawa and Yamauchi (1), and we are pleased they found the study well designed and straightforward (2). Their critiques relate to 1 ) exclusion of reporting insulin sensitivity and 2 ) lack of a significant drug wash-out period prior to β-cell assessment. We did not perform a direct measure of insulin sensitivity using a hyperinsulinemic-euglyceimc clamp as this did not represent one of our main outcomes and would have added a significant technical and financial burden to the study. We attempted to estimate insulin sensitivity using indirect methods such as homeostasis model assessment of …