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We appreciate the critical review of our article by Aizawa and Yamauchi (1), and we are pleased they found the study well designed and straightforward (2). Their critiques relate to 1 ) exclusion of reporting insulin sensitivity and 2 ) lack of a significant drug wash-out period prior to β-cell assessment. We did not perform a direct measure of insulin sensitivity using a hyperinsulinemic-euglyceimc clamp as this did not represent one of our main outcomes and would have added a significant technical and financial burden to the study. We attempted to estimate insulin sensitivity using indirect methods such as homeostasis model assessment of …

diabetes care

Response to Comment on: Harrison et al. <b>β</b>-Cell Function Preservation After 3.5 Years of Intensive Diabetes Therapy. Diabetes Care 2012;35:1406–1412

Response to Comment on: Harrison et al. β-Cell Function Preservation After 3.5 Years of Intensive Diabetes Therapy. Diabetes Care 2012;35:1406–1412