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We thank Dr. Gimenez and Dr. Conget for their comments (1) on our article, recently published in Diabetes Care (2). We acknowledge that our study has several limitations, as it was stated in the discussion, and that the “null hypothesis” should be accepted with caution. In addition, we agree that further large prospective epidemiological studies in type 1 diabetic patients are needed to offer a definite answer on this relevant topic. On the other hand, we believe that existing clinical/epidemiological data …

diabetes care

Response to Comment on: Gruden et al. Severe Hypoglycemia and Cardiovascular Disease Incidence in Type 1 Diabetes: The EURODIAB Prospective Complications Study. Diabetes Care 2012;35:1598–1604