Exenatide Alters Absorption of Hydrocortisone in a Diabetic Patient With Panhypopituitarism: Iatrogenic Adrenal Insufficiency | Zendy

Yukari Fujita | Zendy; Tetsuhiro Kitamura | Zendy; Michio Otsuki | Zendy; Daisuke Tamada | Zendy; Yukiko Tabuchi | Zendy; Junji Kozawa | Zendy; Tetsuyuki Yasuda | Zendy; Kohei Okita | Zendy; Akihisa Imagawa | Zendy; Hideaki Kaneto | Zendy; Tohru Funahashi | Zendy; Iichiro Shimomura | Zendy

Open Access

Exenatide Alters Absorption of Hydrocortisone in a Diabetic Patient With Panhypopituitarism: Iatrogenic Adrenal Insufficiency

Author(s) -

Yukari Fujita,

Tetsuhiro Kitamura,

Michio Otsuki,

Daisuke Tamada,

Yukiko Tabuchi,

Junji Kozawa,

Tetsuyuki Yasuda,

Kohei Okita,

Akihisa Imagawa,

Hideaki Kaneto,

Tohru Funahashi,

Iichiro Shimomura

Publication year - 2012

Publication title -

diabetes care

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 6.636

H-Index - 363

eISSN - 1935-5548

pISSN - 0149-5992

DOI - 10.2337/dc12-1499

Subject(s) - medicine , exenatide , adrenal insufficiency , hydrocortisone , diabetes mellitus , endocrinology , adrenal disorder , hypopituitarism , absorption (acoustics) , type 2 diabetes , insulin resistance , glucose homeostasis , physics , acoustics

Exenatide, which is widely used for patients with type 2 diabetes, inhibits gastric emptying and small intestinal motility (1). We report a diabetic patient with panhypopituitarism who developed general fatigue and appetite loss with hypotension because of absorption delay of hydrocortisone in association with exenatide treatment.A 50-year-old diabetic woman was admitted to our hospital because of poor glycemic control in December 2011. She had been treated with hydrocortisone and L-thyroxine for hypopituitarism as a result from surgeries and radiotherapy for carniopharyngioma. She was started on treatment with 5 μg exenatide twice a day. Nine days after exenatide treatment, the dose was increased …

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