Comment on: Tam et al. Defining Insulin Resistance From Hyperinsulinemic-Euglycemic Clamps. Diabetes Care 2012;35:1605–1610

The euglycemic-hyperinsulinemic clamp is the gold standard for evaluating insulin sensitivity. As such, it is extremely helpful in evaluating the effect of an intervention or in comparing insulin sensitivities between two or more groups. What remains a challenge is to decide the values above which …