Comment on: Gruden et al. Severe Hypoglycemia and Cardiovascular Disease Incidence in Type 1 Diabetes: The EURODIAB Prospective Complications Study. Diabetes Care 2012;35:1598–1604 | Zendy

Marga Giménez | Zendy; Ignacio Conget | Zendy

Open Access

Comment on: Gruden et al. Severe Hypoglycemia and Cardiovascular Disease Incidence in Type 1 Diabetes: The EURODIAB Prospective Complications Study. Diabetes Care 2012;35:1598–1604

Author(s) -

Marga Giménez,

Ignacio Conget

Publication year - 2012

Publication title -

diabetes care

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 6.636

H-Index - 363

eISSN - 1935-5548

pISSN - 0149-5992

DOI - 10.2337/dc12-1248

Subject(s) - medicine , diabetes mellitus , hypoglycemia , disease , type 2 diabetes , incidence (geometry) , type 1 diabetes , intensive care medicine , pediatrics , endocrinology , physics , optics

We have read with a lot of interest the article recently published in Diabetes Care by Gruden et al. (1) suggesting that severe hypoglycemic episodes in patients with type 1 diabetes (T1D) do not increase the risk of cardiovascular disease (CVD). As the authors mentioned in the article (citing one of our previous papers published in Diabetes Care ), a deleterious role of hypoglycemia in not only inflammatory and endothelial markers but also in preclinical atherosclerosis has been reported consistently (2,3). In addition to this, although with substantial limitations related to the intrinsic design of the study, …

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