Open AccessGlucose Derangements in Very Young Children With Cystic Fibrosis and Pancreatic Insufficiency
Author(s) -
Enza Mozzillo,
Valeria Raia,
V. Fattorusso,
Mariateresa Falco,
Angela Sepe,
Fabiola De Gregorio,
Rosa Nugnes,
Giuliana Valerio,
Adriana Franzese
Publication year - 2012
Publication title -
diabetes care
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.636
H-Index - 363
eISSN - 1935-5548
pISSN - 0149-5992
DOI - 10.2337/dc12-0459
Subject(s) - medicine , cystic fibrosis , cystic fibrosis related diabetes , prediabetes , diabetes mellitus , comorbidity , exocrine pancreatic insufficiency , endocrine system , impaired glucose tolerance , pancreatic disease , pediatrics , gastroenterology , endocrinology , pancreas , type 2 diabetes , hormone
Cystic fibrosis–related diabetes (CFRD) is considered the most common comorbidity in patients affected by cystic fibrosis (CF), with a prevalence increasing with age (1). Recently, more attention has been turned to other less severe glucose metabolism derangements (GMD), since prediabetes may be related to increased morbidity (1), and early treatment may improve the clinical course in patients with CF (2). According to recent guidelines released by the Cystic Fibrosis Foundation, the American Diabetes Association, and the Pediatric Endocrine Society, the oral glucose tolerance test (OGTT) is recommended yearly in patients with CF over 10 years of age (3). Some authors recommend annual OGTT after the age of 6 years in CF patients with pancreatic insufficiency (4).In …
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