Response to Comment on: Jeon et al. Helicobacter pylori Infection Is Associated With an Increased Rate of Diabetes. Diabetes Care 2012;35:520–525

We appreciate the commentary by Polyzos et al. (1), which brings to light current evidence on the association between Helicobacter pylori (H. pylori) infection and insulin resistance. As the authors note in their review of our article (2), six of eight studies identified significantly elevated levels of insulin resistance in those infected with H. pylori compared with uninfected control subjects, suggesting a possible mechanistic relationship between H. pylori and diabetes (3). However, all eight studies were cross-sectional in design and most had not adjusted for potential confounders, warranting …