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We have read with interest the letter by Natarajan et al. (1) about our original article published in Diabetes Care (2). Our aim was to evaluate the prognostic effect of insulin resistance on the response to acute stroke thrombolysis. Insulin resistance was quantified with the homeostasis model assessment of insulin resistance (HOMA-IR) using fasting blood samples drawn 24–48 h after admission. We tried to design the study in a way that would minimize the potential confounding effect of hyperglycemia. First, on the basis of the results of the Glycemia in Acute Stroke study demonstrating that glycemia >155 mg/dL is an independent predictor of …

diabetes care

Response to Comment on: Calleja et al. Insulin Resistance Is Associated With a Poor Response to Intravenous Thrombolysis in Acute Ischemic Stroke. Diabetes Care 2011;34:2413–2417