Response to Comments on: Rowan et al. Metformin in Gestational Diabetes: The Offspring Follow-Up (MiG TOFU): Body Composition at 2 Years of Age. Diabetes Care 2011;34:2279–2284 | Zendy

Janet Rowan | Zendy; Elaine Rush | Zendy; Victor Obolonkin | Zendy; Malcolm Battin | Zendy; Trecia A. Wouldes | Zendy; William M. Hague | Zendy

Open Access

Response to Comments on: Rowan et al. Metformin in Gestational Diabetes: The Offspring Follow-Up (MiG TOFU): Body Composition at 2 Years of Age. Diabetes Care 2011;34:2279–2284

Author(s) -

Janet Rowan,

Elaine Rush,

Victor Obolonkin,

Malcolm Battin,

Trecia A. Wouldes,

William M. Hague

Publication year - 2012

Publication title -

diabetes care

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 6.636

H-Index - 363

eISSN - 1935-5548

pISSN - 0149-5992

DOI - 10.2337/dc11-2258

Subject(s) - medicine , metformin , offspring , gestational diabetes , diabetes mellitus , population , rowan , insulin , gestational age , pregnancy , endocrinology , pediatrics , gestation , environmental health , ecology , biology , genetics

We applaud Dr. Rowan and the MiG TOFU (Metformin in Gestational diabetes: The Offspring Follow-Up) investigators for their intense efforts at following the 2-year offspring outcomes from the MiG trial (1). Understanding how in utero exposures impact longer-term offspring consequences is critical. However, we feel compelled to caution against overinterpretation of this study's findings.Of note, 46% of the mothers in the metformin group required insulin to achieve adequate glycemic control (1); therefore, ∼50% in this group actually received both. Although 43% of the total infant cohort received anthropometric measures at 2 years, only ∼15% received dual-energy X-ray absorptiometry (DEXA) scans, thus potentially biasing the results. The absence of any differences in the …

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