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We thank Monnier (1) for his interest in and comments on our article (2). We believe his original work on the relationships between fasting and postprandial hyperglycemia has opened discussion on various important questions, both physiological and clinical (3). In our present analysis, we aimed to extend this work by addressing two of the clinical questions in a larger population than has previously been studied (2). These were 1 ) In a common clinical setting, when oral therapy is no longer successful in keeping A1C below 7%, which form of hyperglycemia is quantitatively most prominent? 2 ) How does intensification of treatment affect hyperglycemic patterns? Our results show that in this …

diabetes care

Response to Comment on: Riddle et al. Contributions of Basal and Postprandial Hyperglycemia Over a Wide Range of A1C Levels Before and After Treatment Intensification in Type 2 Diabetes. Diabetes Care 2011;34:2508–2514