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Hellemons et al. (1) in a post hoc analysis of the Irbesartan in Patients with Type 2 Diabetes and Microalbuminuria (IRMA)-2 trial provocatively showed that the initial reduction of microalbumiuria with an angiotensin receptor blocker (ARB) was independently associated with renoprotection (i.e., independent of blood pressure changes). Antihypertensive medication was removed for a 3-week run-in …

diabetes care

Comment on: Hellemons et al. Initial Angiotensin Receptor Blockade–Induced Decrease in Albuminuria Is Associated With Long-Term Renal Outcome in Type 2 Diabetic Patients With Microalbuminuria: A Post Hoc Analysis of the IRMA-2 Trial. Diabetes Care 2011;34:2078–2083