Response to Comment on: Hermida et al. Influence of Time of Day of Blood Pressure–Lowering Treatment on Cardiovascular Risk in Hypertensive Patients With Type 2 Diabetes. Diabetes Care 2011;34:1270–1276

We thank Rossen and Hansen (1) for their interest in our article (2). The participants represented a consecutive series of patients fulfilling the exclusion/inclusion criteria who were recruited from those referred to the hospital for evaluation by ambulatory blood pressure monitoring (ABPM) mainly to confirm or reject the diagnosis of hypertension inferred by clinic cuff blood pressure measurement. Diagnosis of hypertension in our trial was based on accepted ABPM criteria, i.e., an awake systolic blood pressure (SBP)/diastolic blood pressure (DBP) mean ≥135/85 mmHg and/or an asleep SBP/DBP mean ≥120/70 mmHg (3). Despite a recommended target goal for clinic SBP/DBP in diabetes of 130/80 mmHg, current guidelines do not provide separate ABPM threshold values for patients with and without diabetes (3). Patients with diabetes in our trial …