Advanced Glycation End Products in Children With Type 1 Diabetes: Family Matters? | Zendy

Pascal Barat | Zendy; B. Cammas | Zendy; A. Lacoste | Zendy; Jérôme Harambat | Zendy; V. Vautier | Zendy; Fabienne Nacka | Zendy; Jean-Benoît Corcuff | Zendy

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Advanced Glycation End Products in Children With Type 1 Diabetes: Family Matters?

Author(s) -

Pascal Barat,

B. Cammas,

A. Lacoste,

Jérôme Harambat,

V. Vautier,

Fabienne Nacka,

Jean-Benoît Corcuff

Publication year - 2011

Publication title -

diabetes care

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 6.636

H-Index - 363

eISSN - 1935-5548

pISSN - 0149-5992

DOI - 10.2337/dc11-1398

Subject(s) - medicine , interquartile range , glycated hemoglobin , diabetes mellitus , percentile , sibling , advanced glycation end product , type 1 diabetes , type 2 diabetes , glycation , endocrinology , pediatrics , psychology , developmental psychology , statistics , mathematics

Advanced glycation end product (AGE) burden can be indirectly quantified in vivo by measuring skin autofluorescence (SAF) (1). It has been recently published by Felipe et al. (2) that SAF is correlated with glycated hemoglobin (GHb) but not with mean blood glucose (MBG) in type 1 diabetic children. This suggests that factors besides MBG exposure may be influential in skin AGE generation. In the current study, we have compared SAF in type 1 diabetic children and their nondiabetic sibling.We included 52 type 1 diabetic children, 55% boys, aged 12 (6) years [median (interquartile range: 75th percentile − 25th percentile)], and 28 nondiabetic siblings, 46% boys, aged 11 (6) years. Among diabetic children, the duration of diabetes was 71 (45) …

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