Comment on: Gaillard et al. HDL Dysfunctionality (Paraoxonase) Is Worse in Nondiabetic, Postmenopausal African American Than in White Women. Diabetes Care 2011;34:e19 | Zendy

Alena Viktorínová | Zendy; Soňa Kiňová | Zendy

Open Access

Comment on: Gaillard et al. HDL Dysfunctionality (Paraoxonase) Is Worse in Nondiabetic, Postmenopausal African American Than in White Women. Diabetes Care 2011;34:e19

Author(s) -

Alena Viktorínová,

Soňa Kiňová

Publication year - 2011

Publication title -

diabetes care

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 6.636

H-Index - 363

eISSN - 1935-5548

pISSN - 0149-5992

DOI - 10.2337/dc11-1002

Subject(s) - paraoxonase , medicine , diabetes mellitus , pon1 , aryldialkylphosphatase , postmenopausal women , ethnic group , disease , endocrinology , gerontology , oxidative stress , biochemistry , chemistry , gene , sociology , anthropology , genotype

We read with interest the recent study by Gaillard et al. (1) focused on relationships between paraoxonase (PON1) activity and oxidized LDL and cardiovascular disease (CVD) risk factors in nondiabetic, postmenopausal women. Higher CVD mortality and morbidity in the presence of higher HDL cholesterol is a frequent occurrence in African American women compared with white women. The authors reported the ethnic HDL–related dysfunction (as measured by PON1) in nondiabetic women. They concluded that this paradox may be caused by enhanced LDL oxidation associated with HDL dysfunctionality (lower activity of PON1) in a group …

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