Decreased High Molecular Weight Adiponectin in Sera Is Associated With White Matter Lesions in Japanese Men With Type 2 Diabetes | Zendy

Takayuki Masaki | Zendy; Futoshi Anan | Zendy; Hironobu Yoshimatsu | Zendy

Open Access

Decreased High Molecular Weight Adiponectin in Sera Is Associated With White Matter Lesions in Japanese Men With Type 2 Diabetes

Author(s) -

Takayuki Masaki,

Futoshi Anan,

Hironobu Yoshimatsu

Publication year - 2011

Publication title -

diabetes care

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 6.636

H-Index - 363

eISSN - 1935-5548

pISSN - 0149-5992

DOI - 10.2337/dc11-0796

Subject(s) - adiponectin , medicine , diabetes mellitus , type 2 diabetes , insulin resistance , endocrinology , hyperintensity , magnetic resonance imaging , radiology

The presence of white matter lesions (WML) is an important prognostic factor for the development of stroke in patients with type 2 diabetes (1). Adiponectin, especially high molecular weight (HMW) adiponectin, an adipocyte-derived peptide with antidiabetic and antiatherogenic effects, is known to protect against the initiation and progression of diabetes, atherosclerosis, and insulin resistance (2). However, the relationship between HMW adiponectin and WML in type 2 diabetes has not been fully elucidated. The current study was therefore designed to test the hypothesis that the presences of WML correlates with HMW adiponectin in patients with type 2 diabetes.The 112 Japanese men seen in the Oita Red Cross Hospital between January 2009 and June 2010 for the treatment of type 2 …

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