Open AccessVitamin K2 Supplementation Improves Insulin Sensitivity via Osteocalcin Metabolism: A Placebo-Controlled Trial
Author(s) -
Hyung Jin Choi,
Juyoun Yu,
Hosanna Choi,
Jee Hyun An,
Sang Wan Kim,
Kyong Soo Park,
Hak Chul Jang,
Seong Yeon Kim,
Chan Soo Shin
Publication year - 2011
Publication title -
diabetes care
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.636
H-Index - 363
eISSN - 1935-5548
pISSN - 0149-5992
DOI - 10.2337/dc11-0551
Subject(s) - medicine , osteocalcin , insulin sensitivity , placebo , diabetes mellitus , endocrinology , carbohydrate metabolism , insulin , vitamin , randomized controlled trial , insulin resistance , alkaline phosphatase , biochemistry , alternative medicine , pathology , enzyme , chemistry
Undercarboxylated osteocalcin (ucOC) is reported to function as an endocrine hormone, affecting glucose metabolism in mice (1,2). Vitamin K, which converts ucOC to carboxylated osteocalcin (cOC), has been suggested to regulate glucose metabolism by modulating osteocalcin and/or proinflammatory pathway (3–5).We studied whether modulation of ucOC via vitamin K2 supplementation for 4 weeks affects β-cell function and/or insulin sensitivity in healthy young male subjects. Forty-two healthy young male volunteers received vitamin K2 (menatetrenone; 30 mg; Eisai Co., Japan) or placebo t.i.d. for 4 weeks. Frequently sampled intravenous glucose tolerance test was performed to determine insulin sensitivity index ( S i), acute insulin response to glucose (AIRg), and disposition index (DI) before and after treatment. Adiponectin, interleukin (IL)-6, C-reactive protein (CRP), ucOC, and cOC …
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