Comment on: Boronat et al. Differences in Cardiovascular Risk Profile of Diabetic Subjects Discordantly Classified by Diagnostic Criteria Based on Glycated Hemoglobin and Oral Glucose Tolerance Test. Diabetes Care 2010;33:2671–2673

We read with interest the article by Boronat et al. (1). In that article, individuals with discordant diabetes status by A1C and oral glucose tolerance test (OGTT) had their cardiovascular risk profile evaluated. Those who fulfilled the A1C-based criterion presented greater measures of BMI and waist circumference and lower values for HDL cholesterol than individuals with diabetic OGTT but A1C <6.5% (1). Both elevated A1C (2) and diabetes by OGTT (3) are associated with risks of cardiovascular disease and death compared with fasting glucose in observational studies. To further evaluate the findings by Boronat et al., we analyzed the risk profile of 693 participants (mean age 71.6 years; 39.5% men) from the Rancho Bernardo cohort who were categorized discordantly by …