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We thank d'Annunzio, Russo, and Lorini (1) for their interest in our article (2) related to carbohydrate-insulin variables in youth and later adult pre-diabetes and diabetes. As they noted, normal values of homeostasis model assessment of insulin resistance (HOMA-IR) are increased with sexual maturation. This is consistent with our previous findings in Bogalusa, Louisiana, with children. Svec et al. (3) reported earlier that there was a positive trend of postglucose …

Utility of Childhood Glucose Homeostasis Variables in Predicting Adult Diabetes and Related Cardiometabolic Risk Factors: The Bogalusa Heart Study