Neonatal Diabetes Caused by Pancreatic Agenesia | Zendy

Alessandro Salina | Zendy; Lorenzo Pasquali | Zendy; Concetta Aloi | Zendy; Francesca Lugani | Zendy; Giuseppe d’Annunzio | Zendy; Renata Lorini | Zendy

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Neonatal Diabetes Caused by Pancreatic Agenesia

Author(s) -

Alessandro Salina,

Lorenzo Pasquali,

Concetta Aloi,

Francesca Lugani,

Giuseppe d’Annunzio,

Renata Lorini

Publication year - 2010

Publication title -

diabetes care

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 6.636

H-Index - 363

eISSN - 1935-5548

pISSN - 0149-5992

DOI - 10.2337/dc10-0876

Subject(s) - medicine , agenesis , diabetes mellitus , gestation , pancreas , pediatrics , intrauterine growth restriction , endocrinology , pregnancy , surgery , biology , genetics

Permanent neonatal diabetes (PND) is an extremely rare condition. Few cases of PND caused by pancreas-development failure have been described, and only a few genetic causes have been identified so far (1).We describe a boy with PND caused by pancreas agenesis, currently age 7 years. He is the first child of healthy, unrelated parents. He was born at 35 weeks of gestation, with severe intrauterine growth restriction (weight 1,620 g; length 45 cm). In the first day of life he developed severe hyperglycemia, and neonatal diabetes was diagnosed and treated with insulin, initially intravenously and then subcutaneously. Atrial septal defect was diagnosed in absence of …

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