Immunologic Tolerance to the Insulin Analogue Glulisine

Systemic allergy to insulin is a rare but severe condition. The introduction of human insulin analogues lispro and aspart has considerably decreased the severity of a reaction to insulin (1). However, cases of an allergic reaction to these analogues have also been reported (2). We describe the case of a patient in which severe systemic allergy subsided after glulisine, the latest insulin analogue, was administered.A 33-year-old man was referred to our hospital for the management of type 1 diabetes and insulin allergy. Previously, we showed that intravenous administration using a portable device …