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In a recent issue of Diabetes Care , Thamer et al. (1) addressed the question of whether baseline plasma vitamin C levels influence the outcome of a dietary and exercise intervention in 86 individuals at increased risk for developing type 2 diabetes.Oxidative stress caused by increased formation of reactive oxygen species during physical exercise has previously been proposed to be an important mediator of insulin sensitivity. In a prospective intervention study (2), we have recently shown that regular intake of combined …

High Baseline Vitamin C Levels Do Not Prevent a Positive Outcome of a Lifestyle Intervention