Possible Role of Oxidative Stress in the Pathogenesis of Hypertension | Zendy

Antonio Ceriello | Zendy

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Possible Role of Oxidative Stress in the Pathogenesis of Hypertension

Author(s) -

Antonio Ceriello

Publication year - 2008

Publication title -

diabetes care

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 6.636

H-Index - 363

eISSN - 1935-5548

pISSN - 0149-5992

DOI - 10.2337/dc08-s245

Subject(s) - medicine , nitric oxide , oxidative stress , pathogenesis , diabetes mellitus , vasodilation , superoxide , blood pressure , pathophysiology of hypertension , endocrinology , biochemistry , enzyme , biology

Recently oxidative stress has been proposed as the cause of hypertension. An imbalance in superoxide and nitric oxide production may account for reduced vasodilation, which in turn can favor the development of hypertension. In vitro and in human studies support this hypothesis. The supplementation of antioxidants, particularly in the form of fresh fruit and vegetables, reduces blood pressure, supporting a role for free radicals in hypertension.

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