Visfatin: The Link Between Inflammation and Childhood Obesity | Zendy

George Dedoussis | Zendy; Alexandra Kapiri | Zendy; Anastasia Samara | Zendy; Dimitris Dimitriadis | Zendy; Daniel Lambert | Zendy; Michèle Pfister | Zendy; Gérard Siest | Zendy; Sophie VisvikisSiest | Zendy

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Visfatin: The Link Between Inflammation and Childhood Obesity

Author(s) -

George Dedoussis,

Alexandra Kapiri,

Anastasia Samara,

Dimitris Dimitriadis,

Daniel Lambert,

Michèle Pfister,

Gérard Siest,

Sophie VisvikisSiest

Publication year - 2009

Publication title -

diabetes care

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 6.636

H-Index - 363

eISSN - 1935-5548

pISSN - 0149-5992

DOI - 10.2337/dc08-2304

Subject(s) - adipokine , medicine , adipose tissue , inflammation , obesity , tumor necrosis factor alpha , endocrinology , diabetes mellitus , systemic inflammation , childhood obesity , insulin resistance , overweight

Low-grade inflammation that coexists with obesity has mainly been studied in adults, whereas data in children are limited. Visfatin is a newly discovered adipokine. It is expressed in visceral adipose tissue and has been shown to exert insulin-mimetic effects (1). Although some studies have addressed its relation to obesity, visfatin's biological roles are largely unknown. Besides expression in adipose tissue, visfatin is also expressed in peripheral blood neutrophils upon stimulation by inflammatory factors, such as tumor necrosis factor-α (TNF-α) (2).In light of the rising prevalence of pediatric obesity, it is important to assess the role of visfatin as a predictor of BMI and to unravel its association with inflammation markers. To address this, we measured its …

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