Association Among Sarcoidosis, Type 1 Diabetes, and Charcot Neuro-Osteoarthropathy | Zendy

Dario Pitocco | Zendy; Giuseppe Scavone | Zendy; Francesco Zaccardi | Zendy; Giuseppina Gioffrè | Zendy; T. Musella | Zendy; Francesca Martini | Zendy; Andrea Manto | Zendy; Salvatore Caputo | Zendy; Lorena Mancini | Zendy; Giovanni Ghirlanda | Zendy

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Association Among Sarcoidosis, Type 1 Diabetes, and Charcot Neuro-Osteoarthropathy

Author(s) -

Dario Pitocco,

Giuseppe Scavone,

Francesco Zaccardi,

Giuseppina Gioffrè,

T. Musella,

Francesca Martini,

Andrea Manto,

Salvatore Caputo,

Lorena Mancini,

Giovanni Ghirlanda

Publication year - 2009

Publication title -

diabetes care

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 6.636

H-Index - 363

eISSN - 1935-5548

pISSN - 0149-5992

DOI - 10.2337/dc08-2233

Subject(s) - medicine , sarcoidosis , spinal osteoarthropathy , pathology , bronchoalveolar lavage , mediastinal lymphadenopathy , diabetes mellitus , dermatology , biopsy , endocrinology , lung

Sarcoidosis is a multisystemic inflammatory disease. The association between sarcoidosis and type 1 diabetes is rare. We report two cases of sarcoidosis associated with type 1 diabetes complicated by Charcot neuro-osteoarthropathy (CN).A subject with type 1 diabetes complicated by peripheral and autonomic neuropathy presented cough and cervical lymphadenopathy. The chest computed tomography (CT) scan revealed bilateral hilar lymphadenopathy. A mediastinal lymph node biopsy showed noncaseating giant epithelioid cell granulomas. The immunohistological examination of a follicle showed the prevalence of T-cells. The result of a Mantoux test was negative. Bronchoalveolar lavage was sterile. ACE was absent from bronchoalveolar lavage fluid and increased to 40 UI/l (normal <20 UI/l; colorimetric …

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