Leptin Does Not Directly Regulate the Pancreatic Hormones Amylin and Pancreatic Polypeptide | Zendy

Janice J. Hwang | Zendy; Jean L. Chan | Zendy; Georgia Ntali | Zendy; Dalia Malkova | Zendy; Christos S. Mantzoros | Zendy

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Leptin Does Not Directly Regulate the Pancreatic Hormones Amylin and Pancreatic Polypeptide

Author(s) -

Janice J. Hwang,

Jean L. Chan,

Georgia Ntali,

Dalia Malkova,

Christos S. Mantzoros

Publication year - 2008

Publication title -

diabetes care

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 6.636

H-Index - 363

eISSN - 1935-5548

pISSN - 0149-5992

DOI - 10.2337/dc07-2433

Subject(s) - amylin , medicine , endocrinology , leptin , pancreatic polypeptide , hormone , pancreatic hormone , insulin , diabetes mellitus , obesity , insulin resistance , glucagon , islet

Leptin and the pancreatic hormones amylin and pancreatic polypeptide are being evaluated alone or in combination for the treatment of obesity, but their physiological regulation has not yet been fully elucidated. Thus, we examined whether amylin and pancreatic polypeptide are regulated by caloric intake and/or short- and long-term energy deprivation and whether any potential regulation is mediated by changes in leptin levels.

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