Bloodletting Ameliorates Insulin Sensitivity and Secretion in Parallel to Reducing Liver Iron in Carriers of HFE Gene Mutations | Zendy

Melania Manco | Zendy; Geltrude Mingrone | Zendy; Valério Nobili | Zendy; Francesco Equitani | Zendy

Open Access

Bloodletting Ameliorates Insulin Sensitivity and Secretion in Parallel to Reducing Liver Iron in Carriers of HFE Gene Mutations

Author(s) -

Melania Manco,

Geltrude Mingrone,

Valério Nobili,

Francesco Equitani

Publication year - 2008

Publication title -

diabetes care

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 6.636

H-Index - 363

eISSN - 1935-5548

pISSN - 0149-5992

DOI - 10.2337/dc07-2291

Subject(s) - medicine , hemochromatosis , mutation , hereditary hemochromatosis , bloodletting , diabetes mellitus , gene , genetics , gene mutation , bioinformatics , endocrinology , pathology , biology , alternative medicine

OBJECTIVETo clarify the pathogenesis of diabetes associated with mutations of the hemochromatosis (HFE) gene, 17 carriers, 9 normal glucose tolerant (NGT) and 8 diabetic, were evaluated in an interventional trial.RESEARCH DESIGN AND METHODSAt enrollment and after a 2-year bloodletting period, euglycemic-hyperinsulinemic clamp, oral glucose tolerance test (OGTT), liver histology (nonalcoholic fatty liver disease activity score [NAS]), and liver iron content (LIC) were assessed.RESULTSNGT subjects had significantly higher baseline insulin sensitivity (P

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