Open AccessMarkedly Blunted Metabolic Effects of Fructose in Healthy Young Female Subjects Compared With Male Subjects
Author(s) -
Caroline Couchepin,
KimAnne Lê,
Murielle Bortolotti,
Joana Amarante da Encarnaçao,
Jean-Baptiste Oboni,
Christel Tran,
Philippe Schneiter,
Luc Tappy
Publication year - 2008
Publication title -
diabetes care
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.636
H-Index - 363
eISSN - 1935-5548
pISSN - 0149-5992
DOI - 10.2337/dc07-2001
Subject(s) - medicine , endocrinology , hypertriglyceridemia , fructose , insulin resistance , triglyceride , insulin , metabolic syndrome , diabetes mellitus , cholesterol , biology , biochemistry
OBJECTIVE—To compare the metabolic effects of fructose in healthy male and female subjects. RESEARCH DESIGN AND METHODS—Fasting metabolic profile and hepatic insulin sensitivity were assessed by means of a hyperglycemic clamp in 16 healthy young male and female subjects after a 6-day fructose overfeeding. RESULTS—Fructose overfeeding increased fasting triglyceride concentrations by 71 vs. 16% in male vs. female subjects, respectively (P < 0.05). Endogenous glucose production was increased by 12%, alanine aminotransferase concentration was increased by 38%, and fasting insulin concentrations were increased by 14% after fructose overfeeding in male subjects (all P < 0.05) but were not significantly altered in female subjects. Fasting plasma free fatty acids and lipid oxidation were inhibited by fructose in male but not in female subjects. CONCLUSIONS—Short-term fructose overfeeding produces hypertriglyceridemia and hepatic insulin resistance in men, but these effects are markedly blunted in healthy young women.