The Protein Tyrosine Phosphatase Nonreceptor 22 (PTPN22) Is Associated With High GAD Antibody Titer in Latent Autoimmune Diabetes in Adults | Zendy

Antonio Petrone | Zendy; C Suraci | Zendy; Marco Capizzi | Zendy; Andrea Giaccari | Zendy; Emanuele Bosi | Zendy; Claudio Tiberti | Zendy; Efisio Cossu | Zendy; Paolo Pozzilli | Zendy; Alberto Falorni | Zendy; Raffaella Buzzetti | Zendy

Open Access

The Protein Tyrosine Phosphatase Nonreceptor 22 (PTPN22) Is Associated With High GAD Antibody Titer in Latent Autoimmune Diabetes in Adults

Author(s) -

Antonio Petrone,

C Suraci,

Marco Capizzi,

Andrea Giaccari,

Emanuele Bosi,

Claudio Tiberti,

Efisio Cossu,

Paolo Pozzilli,

Alberto Falorni,

Raffaella Buzzetti

Publication year - 2008

Publication title -

diabetes care

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 6.636

H-Index - 363

eISSN - 1935-5548

pISSN - 0149-5992

DOI - 10.2337/dc07-1457

Subject(s) - medicine , ptpn22 , diabetes mellitus , autoimmune diabetes , protein tyrosine phosphatase , antibody , titer , autoimmunity , immunology , endocrinology , genetics , genotype , receptor , biology , gene , single nucleotide polymorphism

We previously demonstrated the presence of two different populations among individuals with adult-onset autoimmune diabetes: those having either a high titer or a low titer of antibodies to GAD (GADAs). Protein tyrosine phosphatase nonreceptor type 22 (PTPN22) has been identified as a new susceptibility gene for type 1 diabetes and other autoimmune diseases. The aim of the present study was to evaluate whether the phenotypic heterogeneity of adult-onset autoimmune diabetes based on the GADA titer is associated with the PTPN22 C1858T polymorphism.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research