Pioglitazone Use and Heart Failure in Patients With Type 2 Diabetes and Preexisting Cardiovascular Disease
Author(s) -
Erland Erdmann,
B Charbonnel,
Robert A. Wilcox,
Allan M. Skene,
Massimo MassiBenedetti,
John Yates,
Meng H. Tan,
Robert G. Spanheimer,
Eberhard Standl,
John Dormandy
Publication year - 2007
Publication title -
diabetes care
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.636
H-Index - 363
eISSN - 1935-5548
pISSN - 0149-5992
DOI - 10.2337/dc07-0717
Subject(s) - pioglitazone , medicine , heart failure , placebo , cardiology , clinical endpoint , diabetes mellitus , type 2 diabetes , heart disease , adverse effect , clinical trial , endocrinology , pathology , alternative medicine
PROspective pioglitAzone Clinical Trial In macroVascular Events (PROactive) enrolled patients with type 2 diabetes and preexisting cardiovascular disease. These patients were at high risk for heart failure, so any therapeutic benefit could potentially be offset by risk of associated heart failure mortality. We analyzed the heart failure cases to assess the effects of treatment on morbidity and mortality after reports of serious heart failure.
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