Benfotiamine Prevents Macro- and Microvascular Endothelial Dysfunction and Oxidative Stress Following a Meal Rich in Advanced Glycation End Products in Individuals With Type 2 Diabetes | Zendy

Alin Stirban | Zendy; Monica Negrean | Zendy; Bernd Stratmann | Zendy; Thomas Gawlowski | Zendy; Tina Horstmann | Zendy; C Götting | Zendy; K Kleesiek | Zendy; Michaela Mueller-Roesel | Zendy; Theodor Koschinsky | Zendy; Jaime Uribarri | Zendy; Helen Vlassara | Zendy; Diethelm Tschoepe | Zendy

Open Access

Benfotiamine Prevents Macro- and Microvascular Endothelial Dysfunction and Oxidative Stress Following a Meal Rich in Advanced Glycation End Products in Individuals With Type 2 Diabetes

Author(s) -

Alin Stirban,

Monica Negrean,

Bernd Stratmann,

Thomas Gawlowski,

Tina Horstmann,

C Götting,

K Kleesiek,

Michaela Mueller-Roesel,

Theodor Koschinsky,

Jaime Uribarri,

Helen Vlassara,

Diethelm Tschoepe

Publication year - 2006

Publication title -

diabetes care

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 6.636

H-Index - 363

eISSN - 1935-5548

pISSN - 0149-5992

DOI - 10.2337/dc06-0531

Subject(s) - endothelial dysfunction , postprandial , reactive hyperemia , medicine , oxidative stress , endocrinology , glycation , diabetes mellitus , endothelium , type 2 diabetes , vasodilation

Diabetes is characterized by marked postprandial endothelial dysfunction induced by hyperglycemia, hypertriglyceridemia, advanced glycation end products (AGEs), and dicarbonyls (e.g., methylglyoxal [MG]). In vitro hyperglycemia-induced MG formation and endothelial dysfunction could be blocked by benfotiamine, but in vivo effects of benfotiamine on postprandial endothelial dysfunction and MG synthesis have not been investigated in humans until now.

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