Impaired Insulin Secretion After Prenatal Exposure to the Dutch Famine | Zendy

Susanne R. de Rooij | Zendy; Rebecca C. Painter | Zendy; David I. W. Phillips | Zendy; Clive Osmond | Zendy; Robert P.J. Michels | Zendy; Ian F. Godsland | Zendy; Patrick M. Bossuyt | Zendy; Otto P. Bleker | Zendy; Tessa J. Roseboom | Zendy

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Impaired Insulin Secretion After Prenatal Exposure to the Dutch Famine

Author(s) -

Susanne R. de Rooij,

Rebecca C. Painter,

David I. W. Phillips,

Clive Osmond,

Robert P.J. Michels,

Ian F. Godsland,

Patrick M. Bossuyt,

Otto P. Bleker,

Tessa J. Roseboom

Publication year - 2006

Publication title -

diabetes care

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 6.636

H-Index - 363

eISSN - 1935-5548

pISSN - 0149-5992

DOI - 10.2337/dc06-0460

Subject(s) - famine , medicine , insulin , endocrinology , gestation , glucose tolerance test , impaired glucose tolerance , insulin resistance , diabetes mellitus , pregnancy , biology , political science , law , genetics

We previously reported that people prenatally exposed to famine during the Dutch Hunger Winter of 1944-1945 have higher 2-h glucose concentrations after an oral glucose tolerance test in later life. We aimed to determine whether this association is mediated through alterations in insulin secretion, insulin sensitivity, or a combination of both.

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