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In their comment, González-Ortiz et al. cited their study that reported that in a randomized, doubleblind, placebo-controlled clinical trial of 12 overweight or obese male volunteers, of whom 6 received celecoxib for 4 weeks, the insulin sensitivity after celecoxib treatment was significantly higher compared with the basal estimation.Peer Reviewe

diabetes

Response to Comment on Francés et al. Hepatic Cyclooxygenase-2 Expression Protects Against Diet-Induced Steatosis, Obesity, and Insulin Resistance. Diabetes 2015;64:1522–1531