Distinct Characteristics Between Perivascular and Subcutaneous Adipose-Derived Stem Cells | Zendy

Yao Xie | Zendy; Yongli Ji | Zendy; Yunrui Lu | Zendy; Yuankun Ma | Zendy; Hui Ni | Zendy; Jian Shen | Zendy; Hong Ma | Zendy; Chunna Jin | Zendy; Yuwen Chen | Zendy; Yan Lin | Zendy; Meixiang Xiang | Zendy

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Distinct Characteristics Between Perivascular and Subcutaneous Adipose-Derived Stem Cells

Author(s) -

Yao Xie,

Yongli Ji,

Yunrui Lu,

Yuankun Ma,

Hui Ni,

Jian Shen,

Hong Ma,

Chunna Jin,

Yuwen Chen,

Yan Lin,

Meixiang Xiang

Publication year - 2021

Publication title -

diabetes

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.219

H-Index - 330

eISSN - 1939-327X

pISSN - 0012-1797

DOI - 10.2337/db20-1129

Subject(s) - adipose tissue , stem cell , biology , cell , pathology , phenotype , microbiology and biotechnology , medicine , endocrinology , biochemistry , gene , genetics

Adipose-derived stem cells (ADSCs) can differentiate into vascular lineages and participate in vascular remodeling. Perivascular ADSCs (PV-ADSCs) draw attention because of their unique location. The heterogeneity of subcutaneous (SUB) and abdominal ADSCs were well addressed, but PV-ADSCs’ heterogeneity has not been investigated. In this study, we applied single-cell analysis to compare SUB-ADSCs and PV-ADSCs regarding their subpopulations, functions, and cell fates. We uncovered four subpopulations of PV-ADSCs (Dpp4+, Col4a2+/Icam1+, Clec11a+/Cpe+, and Sult1e1+ cells), among which the Clec11a+ subpopulation potentially participated in and regulated PV-ADSC differentiation toward a smooth muscle cell (SMC) phenotype. Distinct characteristics between PV-ADSCs and SUB-ADSCs were revealed.

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