Plasma 25-Hydroxyvitamin D Concentration and Risk of Islet Autoimmunity | Zendy

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Plasma 25-Hydroxyvitamin D Concentration and Risk of Islet Autoimmunity

Author(s) -

Jill M. Norris,

Hye Seung Lee,

Brittni N. Frederiksen,

Iris Erlund,

Ulla Uusitalo,

Jimin Yang,

Åke Lernmark,

Olli Simell,

Jorma Toppari,

Marian Rewers,

AnetteG. Ziegler,

JinXiong She,

Suna Önengüt-Gümüşcü,

WeiMin Chen,

Stephen S. Rich,

Jouko Sundvall,

Beena Akolkar,

Jeffrey P. Krischer,

Suvi Μ. Virtanen,

William Hagopian,

Kimberly Bautista,

Judith Baxter,

Ruth Bedoy,

Daniel Felipe-Morales,

Kimberly A. Driscoll,

Brigitte I. Frohnert,

Patricia Gesualdo,

Michelle Hoffman,

Rachel Karban,

Edwin Liu,

Adela Samper-Imaz,

Andrea K. Steck,

Kathleen Waugh,

Hali Wright,

Annika Adamsson,

Suvi Ahonen,

Heikki Hyöty,

Jorma Ilonen,

Sanna Jokipuu,

Tiina Kallio,

Leena Eklund Karlsson,

Miia Kähönen,

Mikael Knip,

Lea Kovanen,

Mirva Koreasalo,

Kalle Kurppa,

Tiina Latva-aho,

Maria Lönnrot,

Elina Mäntymäki,

Katja Multasuo,

Juha Mykkänen,

Tiiiininen,

Sari Niinistö,

Mia Nyblom,

Petra Rajala,

Jenna Rautanen,

Anne Riikonen,

Mika Riikonen,

Jenni Rouhiainen,

Minna Romo,

Tuula Simell,

Ville Simell,

Maija Sjöberg,

Aino Stenius,

Maria Leppänen,

Sini Vainionpää,

Eeva Varjonen,

Riitta Veijola,

Mari Vähä-Mäkilä,

Katri Lindfors,

Jin-Xiong She,

Desmond Schatz,

Diane Hopkins,

Leigh Steed,

Jamie Thomas,

Janey Adams,

Katherine Silvis,

Michael J. Haller,

Melissa Gardiner,

Richard McIndoe,

Ashok Sharma,

Joshua Williams,

Gabriela Young,

Stephen W. Anderson,

Laura M. Jacobsen,

Anette G. Ziegler,

Andreas Beyerlein,

Ezio Bonifacio,

Michael Hummel,

Sandra Hummel,

Kristina Foterek,

Nicole Janz,

Mathilde Kersting,

Annette Knopff,

Sibylle Koletzko,

Claudia Peplow,

Roswith Roth,

Marlon Scholz,

Joanna Stock,

Katharina Warncke,

Lorena Wendel,

Christiane Winkler,

Daniel Agardh,

Carin Andrén Aronsson,

Maria Ask,

Jenny Bremer,

Ulla-Marie Carlsson,

Corrado Cilio,

Emelie Ericson-Hallström,

Lina Fransson,

Thomas Gard,

Joanna Gerardsson,

Rasmus Bennet,

Monica Hansen,

Gertie Hansson,

Susanne Hyberg,

Fredrik Johansen,

Berglind Jónsdóttir,

Helena Elding Larsson,

Marielle Lindström,

Markus Lundgren,

Maria Månsson-Martinez,

Maria Markan,

Jessica Melin,

Zeliha Mestan,

Karin Ottosson,

Kobra Rahmati,

Anita Ramelius,

Falastin Salami,

Sara Sibthorpe,

Birgitta Janerot-Sjöberg,

Ulrica Swartling,

Evelyn Tekum Amboh,

Carina Törn,

Anne Wallin,

Åsa Wimar,

Sofie Åberg,

Michael Killian,

Claire Cowen Crouch,

Jennifer Skidmore,

Josephine Carson,

Maria Dalzell,

Kayleen Dunson,

Rachel Hervey,

Corbin Johnson,

Rachel Lyons,

Arlene Meyer,

Denise Mulenga,

Alexander W. Tarr,

Morgan Uland,

John M. Willis,

Dorothy Becker,

Margaret Franciscus,

MaryEllen Dalmagro-Elias Smith,

Ashi Daftary,

Mary Beth Klein,

Chrystal Yates,

Michael Abbondondolo,

Sarah Austin-Gonzalez,

Maryouri Avendano,

Sandra Baethke,

Rasheedah Brown,

Brant Burkhardt,

Martha Butterworth,

Joanna Clasen,

David Cuthbertson,

Christopher Eberhard,

Steven Fiske,

Dena Garcia,

Jennifer Garmeson,

Veena Gowda,

Kathleen Heyman,

Francisco Perez Laras,

HyeSeung Lee,

Shu Liu,

Xiang Liu,

Kristian Lynch,

Jamie Malloy,

Cristina McCarthy,

Steven Meulemans,

Hemang Parikh,

Chris Shaffer,

Laura Smith,

Susan Smith,

Noah Sulman,

Roy Tamura,

Kendra Vehik,

Ponni Vijayakandipan,

Keith Wood,

Kasia Bourcier,

Thomas Briese,

Suzanne Bennett Johnson,

Eric W. Triplett,

Liping Yu,

Dongmei Miao,

Polly J. Bingley,

Alistair Williams,

Kyla Chandler,

Saba Rokni,

Claire Williams,

Rebecca C. Wyatt,

Gifty George,

Sian Grace,

Irma Salminen,

Jaana Leiviskä,

Nina Kangas,

Petra Arohonka,

M Kellis,

Steven J. Mack,

Anna Lisa Fear,

Sandra Ke,

Niveen Mulholland,

Emily Farber,

Rebecca Roche Pickin,

Jordan P. Davis,

Dan Gallo,

Jessica Bonnie,

Paul Campolieto

Publication year - 2017

Publication title -

diabetes

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.219

H-Index - 330

eISSN - 1939-327X

pISSN - 0012-1797

DOI - 10.2337/db17-0802

Subject(s) - vitamin d and neurology , calcitriol receptor , medicine , endocrinology , odds ratio , diabetes mellitus , type 1 diabetes , allele , case control study , vitamin d deficiency , autoimmunity , gastroenterology , biology , gene , genetics , disease

We examined the association between plasma 25-hydroxyvitamin D [25(OH)D] concentration and islet autoimmunity (IA) and whether vitamin D gene polymorphisms modify the effect of 25(OH)D on IA risk. We followed 8,676 children at increased genetic risk of type 1 diabetes at six sites in the U.S. and Europe. We defined IA as positivity for at least one autoantibody (GADA, IAA, or IA-2A) on two or more visits. We conducted a risk set sampled nested case-control study of 376 IA case subjects and up to 3 control subjects per case subject. 25(OH)D concentration was measured on all samples prior to, and including, the first IA positive visit. Nine polymorphisms in VDR, CYP24A, CYP27B1, GC, and RXRA were analyzed as effect modifiers of 25(OH)D. Adjusting for HLA-DR-DQ and ancestry, higher childhood 25(OH)D was associated with lower IA risk (odds ratio = 0.93 for a 5 nmol/L difference; 95% CI 0.89, 0.97). Moreover, this association was modified by VDR rs7975232 (interaction P = 0.0072), where increased childhood 25(OH)D was associated with a decreasing IA risk based upon number of minor alleles: 0 (1.00; 0.93, 1.07), 1 (0.92; 0.89, 0.96), and 2 (0.86; 0.80, 0.92). Vitamin D and VDR may have a combined role in IA development in children at increased genetic risk for type 1 diabetes.

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