Deletion of Class A Scavenger Receptor Deteriorates Obesity-Induced Insulin Resistance in Adipose Tissue | Zendy

Xudong Zhu | Zendy; Guijuan Zong | Zendy; Liu Zhu | Zendy; Yuchen Jiang | Zendy; Ke Ma | Zendy; Hanwen Zhang | Zendy; Yan Zhang | Zendy; Hui Bai | Zendy; Qing Yang | Zendy; Jingjing Ben | Zendy; Xiaoyu Li | Zendy; Yong Xu | Zendy; Qi Chen | Zendy

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Deletion of Class A Scavenger Receptor Deteriorates Obesity-Induced Insulin Resistance in Adipose Tissue

Author(s) -

Xudong Zhu,

Guijuan Zong,

Liu Zhu,

Yuchen Jiang,

Ke Ma,

Hanwen Zhang,

Yan Zhang,

Hui Bai,

Qing Yang,

Jingjing Ben,

Xiaoyu Li,

Yong Xu,

Qi Chen

Publication year - 2013

Publication title -

diabetes

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.219

H-Index - 330

eISSN - 1939-327X

pISSN - 0012-1797

DOI - 10.2337/db13-0815

Subject(s) - adipose tissue , insulin resistance , scavenger receptor , macrophage polarization , endocrinology , medicine , inflammation , adipose tissue macrophages , receptor , biology , insulin receptor , white adipose tissue , microbiology and biotechnology , activator (genetics) , insulin , macrophage , in vitro , biochemistry , cholesterol , lipoprotein

Chronic low-grade inflammation, particularly in the adipose tissue, orchestrates obesity-induced insulin resistance. In this process, polarized activation of macrophages plays a crucial role. However, how macrophages contribute to insulin resistance remains obscure. Class A scavenger receptor (SR-A) is a pattern recognition receptor primarily expressed in macrophages. Through a combination of in vivo and in vitro studies, we report here that deletion of SR-A resulted in reduced insulin sensitivity in obese mice. The anti-inflammatory virtue of SR-A was accomplished by favoring M2 macrophage polarization in adipose tissue. Moreover, we demonstrate that lysophosphatidylcholine (LPC) served as an obesity-related endogenous ligand for SR-A promoting M2 macrophage polarization by activation of signal transducer and activator of transcription 6 signaling. These data have unraveled a clear mechanistic link between insulin resistance and inflammation mediated by the LPC/SR-A pathway in macrophages.

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