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Using α-cell–specific knockout of the mitochondrial uncoupling protein 2 (UCP2), Allister et al. (1) recently provided evidence for involvement of this protein in glucose regulation of glucagon release. This is an interesting and potentially important contribution with regard to the possible involvement of UCP2. However, the authors do not seem to notice that their data contradict the promoted model. The study focuses on intrinsic regulation of secretion, …

Comment on: Allister et al. UCP2 Regulates the Glucagon Response to Fasting and Starvation. Diabetes 2013;62:1623–1633