Comment on: Teeuwisse et al. Short-Term Caloric Restriction Normalizes Hypothalamic Neuronal Responsiveness to Glucose Ingestion in Patients With Type 2 Diabetes. Diabetes 2012;61:3255–3259

We wish to thank Drs. Heni, Kullmann, and Fritsche (1) for their interesting comments on our article (2). Their findings that plasma glucose and insulin are associated with hypothalamic activity (3,4) are of importance for the clarification of the complex relationship between the brain and feeding. We agree that glucose and insulin levels are potential triggers for the hypothalamic response to glucose ingestion. This response can be accurately assessed using functional magnetic resonance imaging.However, the importance of plasma glucose in the context of hypothalamic activity after glucose …