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We applaud the thoughtful letter from Vialettes and Valero (1) bringing attention to endoplasmic reticulum (ER) stress as a potential mechanism influencing the decline in β-cell function observed in individuals with type 1 diabetes. We agree that it is a plausible mechanism underlying the preservation of C-peptide seen with aggressive correction of metabolic dysregulation and look forward …

diabetes

Response to Comment on: Greenbaum et al. Through the Fog: Recent Clinical Trials to Preserve β-Cell Function in Type 1 Diabetes. Diabetes 2012;61:1323–1330