Response to Comment on: Greenbaum et al. Through the Fog: Recent Clinical Trials to Preserve β-Cell Function in Type 1 Diabetes. Diabetes 2012;61:1323–1330 | Zendy

Carla J. Greenbaum | Zendy; Desmond Schatz | Zendy; Michael J. Haller | Zendy; Srinath Sanda | Zendy

Open Access

Response to Comment on: Greenbaum et al. Through the Fog: Recent Clinical Trials to Preserve β-Cell Function in Type 1 Diabetes. Diabetes 2012;61:1323–1330

Author(s) -

Carla J. Greenbaum,

Desmond Schatz,

Michael J. Haller,

Srinath Sanda

Publication year - 2012

Publication title -

diabetes

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.219

H-Index - 330

eISSN - 1939-327X

pISSN - 0012-1797

DOI - 10.2337/db12-0914

Subject(s) - endoplasmic reticulum , mechanism (biology) , type 2 diabetes , function (biology) , diabetes mellitus , clinical trial , medicine , endocrinology , neuroscience , psychology , biology , microbiology and biotechnology , philosophy , epistemology

We applaud the thoughtful letter from Vialettes and Valero (1) bringing attention to endoplasmic reticulum (ER) stress as a potential mechanism influencing the decline in β-cell function observed in individuals with type 1 diabetes. We agree that it is a plausible mechanism underlying the preservation of C-peptide seen with aggressive correction of metabolic dysregulation and look forward …

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