Response to Comment on: Schuit et al. β-Cell–Specific Gene Repression: A Mechanism to Protect Against Inappropriate or Maladjusted Insulin Secretion? Diabetes 2012;61:969–975 | Zendy

Frans Schuit | Zendy

Open Access

Response to Comment on: Schuit et al. β-Cell–Specific Gene Repression: A Mechanism to Protect Against Inappropriate or Maladjusted Insulin Secretion? Diabetes 2012;61:969–975

Author(s) -

Frans Schuit

Publication year - 2012

Publication title -

diabetes

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.219

H-Index - 330

eISSN - 1939-327X

pISSN - 0012-1797

DOI - 10.2337/db12-0888

Subject(s) - psychological repression , mechanism (biology) , insulin , secretion , diabetes mellitus , biology , gene , endocrinology , genetics , gene expression , physics , quantum mechanics

Thank you for the invitation to respond to the comment by Rutter and Pullen (1). We are aware of the original work by the Rutter laboratory on LDHA and MCT1 (2,3) and cited it before (4) and in the Perspective (5). However, with the limitation of 50 references in the Perspective, some original research could not be cited, and we apologize for that.We strongly disagree, however, with the claim from Rutter and Pullen to be the first to discover islet-specific gene repression through bioinformatic analysis (1). It should be made clear that until 2006 research on lactate dehydrogenase and moncarboxylate transporter 1 was conducted …

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research