Response to Comment on: Marquez et al. Low-Frequency Variants in HMGA1 Are Not Associated With Type 2 Diabetes Risk. Diabetes 2012;61:524–530 | Zendy

Philippe Froguel | Zendy; Marcel Marquez | Zendy; Stéphane Cauchi | Zendy

Open Access

Response to Comment on: Marquez et al. Low-Frequency Variants in HMGA1 Are Not Associated With Type 2 Diabetes Risk. Diabetes 2012;61:524–530

Author(s) -

Philippe Froguel,

Marcel Marquez,

Stéphane Cauchi

Publication year - 2012

Publication title -

diabetes

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.219

H-Index - 330

eISSN - 1939-327X

pISSN - 0012-1797

DOI - 10.2337/db12-0800

Subject(s) - type 2 diabetes , disappointment , surprise , diabetes mellitus , medicine , psychology , endocrinology , social psychology

We read with surprise and disappointment the comment in Diabetes by Brunetti et al. (1) who made unfair comments about our negative study published in the same journal (2). Therefore, we felt the necessity to provide a point-by-point response to all raised issues.1. In contrast to the claims by Brunetti et al. (1), we have never reported in meeting abstracts any consistent associations between HMGA1 variants and type 2 diabetes (T2D) risk when all French samples were analyzed together. Trends observed in obese subjects were not confirmed in a larger number of individuals and BMI was finally found not to …

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