Comment on: Turban et al. Optimal Elevation of β-Cell 11β-Hydroxysteroid Dehydrogenase Type 1 Is a Compensatory Mechanism That Prevents High-Fat Diet–Induced β-Cell Failure. Diabetes 2012;61:642–652 | Zendy

JunLi Liu | Zendy; Coimbatore B. Srikant | Zendy; Subrata Chowdhury | Zendy

Open Access

Comment on: Turban et al. Optimal Elevation of β-Cell 11β-Hydroxysteroid Dehydrogenase Type 1 Is a Compensatory Mechanism That Prevents High-Fat Diet–Induced β-Cell Failure. Diabetes 2012;61:642–652

Author(s) -

JunLi Liu,

Coimbatore B. Srikant,

Subrata Chowdhury

Publication year - 2012

Publication title -

diabetes

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.219

H-Index - 330

eISSN - 1939-327X

pISSN - 0012-1797

DOI - 10.2337/db12-0556

Subject(s) - type 2 diabetes , mechanism (biology) , medicine , endocrinology , elevation (ballistics) , biology , cell , dehydrogenase , diabetes mellitus , enzyme , genetics , biochemistry , philosophy , geometry , mathematics , epistemology

Turban et al. (1) recently reported a surprise finding that moderately elevated 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) expression in the pancreatic β-cells promoted a compensation against high-fat (HF) diet–induced β-cell failure because glucocorticoids are well established to impair insulin secretion and cause β-cell death and insulin resistance in key insulin targets. Rather than accepting the …

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