Response to Comment on: Kim et al. Deficiency for Costimulatory Receptor 4-1BB Protects Against Obesity-Induced Inflammation and Metabolic Disorders. Diabetes 2011;60:3159–3168 | Zendy

Rina Yu | Zendy

Open Access

Response to Comment on: Kim et al. Deficiency for Costimulatory Receptor 4-1BB Protects Against Obesity-Induced Inflammation and Metabolic Disorders. Diabetes 2011;60:3159–3168

Author(s) -

Rina Yu

Publication year - 2012

Publication title -

diabetes

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.219

H-Index - 330

eISSN - 1939-327X

pISSN - 0012-1797

DOI - 10.2337/db12-0356

Subject(s) - inflammation , diabetes mellitus , receptor , medicine , endocrinology , immunology , obesity

I thank Drs. Gomez-Mejiba and Ramirez for their letter (1) and for initiating further discussion of possible mechanisms underlying the effects of 4-1BB stimulation/deficiency on the obesity-induced responses of T cells/macrophages in adipose tissue (2,3), and how both conditions can lead to protection against metabolic complications.Obesity-induced adipose inflammation is currently considered to create an optimal environment for autoimmune effects to take root (4). 4-1BB stimulation with agonistic anti–4-1BB antibody is known to attenuate many …

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