Response to Comment on: Gorboulev et al. Na+-d-glucose Cotransporter SGLT1 Is Pivotal for Intestinal Glucose Absorption and Glucose-Dependent Incretin Secretion. Diabetes 2012;61:187–196

In response to the commentary of Professor Kellett (1), we would like to clarify the following points. The data reported in our article (2) confirm the observation that SGLT1-mediated D-glucose uptake in the presence of a high D-glucose concentration in the small intestinal lumen mediates translocation of GLUT2 to the luminal membrane of the enterocytes; however, they contradict the hypothesis that GLUT2 is the major pathway of D-glucose absorption when glucose is plentiful (3–6). Comparing SGLT1-mediated and GLUT2-mediated glucose uptake into isolated brush-border membrane (BBM) vesicles, we present evidence that SGLT1 transports about 90% of D-glucose into the enterocytes in the presence of high luminal glucose whereas only about 10% …