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Maruthur et al. (1) showed that European genetic admixture is inversely related to HbA1c levels among African Americans, although admixture explained less than 1% of the variance in HbA1c. Others have reported that genetic factors account for ∼60% of the variance in HbA1c (2). For unclear reasons, African Americans express higher HbA1c levels than Caucasians with similar blood glucose values (3 …

Comment on: Maruthur et al. Does Genetic Ancestry Explain Higher Values of Glycated Hemoglobin in African Americans? Diabetes 2011;60:2434–2438